Hotel Near Medical Center San Antonio & Six Flags Texas is located off Interstate 10 and is 20 minutes away from downtown San Antonio. Our hotel's location and extra amenities create an unforgettable stay for our guests. The Holiday Inn Express & Suites Medical-Six Flags is situated near many of San Antonio’s most popular attractions, medical facilities, and local businesses. Corporate guests will appreciate the convenient access to USAA, Valero Corporate HQ, UnitedHealth Group, San Antonio Medical Center, and the FBI building. Guests will also enjoy access to our 24-hour Business Center with free high-speed Internet and complimentary Express Start hot breakfast bar. Nearby attractions include Six Flags Fiesta Texas amusement park, SeaWorld Marine Park the historic Alamo landmark and museum, the Alamodome multipurpose facility, AT&T Center, San Antonio Zoo and Aquarium, the San Antonio Botanical Garden and the McNay Art Museum. The nearby San Antonio River Walk is one of the city's most popular destinations and features numerous sidewalk eateries, pubs and live entertainment. Our quick access to the University of San Antonio Texas makes it easy to cheer on the Texas Roadrunners. Our hotel is just minutes away from the iconic River Walk and the famous La Cantera Mall.