- Best Western Mystic Hotel
- Hampton Inn & Suites Mystic
- Hilton Mystic
- Holiday Inn Express Mystic, An IHG Hotel
- House of 1833 Bed & Breakfast & Gardens
- Howard Johnson by Wyndham Mystic
- Hyatt Place Mystic
- Inn at Mystic
- Residence Inn by Marriott Mystic Groton
- Spark by Hilton Mystic Groton
- Taber Inn
- The Whaler's Inn